The Foundation seeks to promote and facilitate collaborative research on the pathogenesis, early diagnosis, and treatment of upper gastrointestinal malignancies. We support high quality, innovative, and transformative translational and bench research to improve the understanding of the biology of these diseases, identification of potential novel therapeutic targets, or in the development and evaluation of novel biomarkers for early diagnosis and treatment. Pre-clinical research, basic mechanistic studies, genomic/epigenomic studies, as well as epidemiologic studies may also be supported.
Esophageal adenocarcinoma (EAC) is the fastest growing lethal malignancy in the West. Gastro-esophageal reflux disease (GERD) is a chronic-inflammatory disorder associated with an 8 fold increased risk of EAC. Interactions between the epithelium and the underlying stromal layer may be critical to elucidating the link between gastrointestinal inflammatory disorders such as GERD and esophageal cancer. The spindle-shaped myofibroblast, one of the cell types in the esophageal stroma, is a focus of our laboratory. Our work suggests that esophageal myofibroblasts regulate mucosal inflammation, injury, and repair processes in the human esophagus via secretion of a number of signaling mediators, including cytokines and growth factors. With the DeGregorio Foundation grant, we will investigate these interactions by adapting myofibroblasts from GERD patients into 3D organotypic (OTC) models that recapitulate human esophageal stratified squamous epithelium. We hope to delineate the inter-cellular cross talk in GERD that when disrupted leads to esophageal carcinogenesis
He will begin clinical trials of a potential approach for reversing precancerous stomach lesions. Check back, we have exciting details to come!
Tony E. Godfrey, PhD, Associate Chair, Surgical Research and Associate Professor of Surgery, Boston University School of Medicine, earned a bachelor’s of science degree in biochemistry from Brunel University in England, followed by a doctorate in molecular biology and biochemistry, also from Brunel. He attended the University of California, San Francisco, for postdoctoral fellowships and managed UCSF’s Genome Analysis Core Facility.
Most recently, Dr. Godfrey was a Research Associate Professor in the Department of Surgery at the University of Rochester Medical Center in Rochester, NY. Prior to this he was an Associate Professor of Pathology at Mt. Sinai School of Medicine in New York, NY.
Dr. Godfrey’s research is focused on cancer genetics and molecular pathology. Research projects use state-of-the-art genetic and genomic approaches to address clinical needs in the areas of cancer diagnosis, prognosis and therapy. Currently the major focus of Dr. Godfrey’s research is on Barrett’s esophagus and esophageal adenocarcinoma; a tumor with rapidly increasing incidence in the United States and other western countries. The Godfrey lab works closely with translational research teams comprised of surgeons, pathologists and oncologists in order to develop new molecular approaches to cancer detection, staging and treatment.
Click Here to read more about Dr. Godfrey’s research and a complete list of his published reports
EHE International’s generous donation of their window display at 10 Rockefeller Center increased awareness of Stomach and Esophageal Cancer and the need for funding research into the causes, prevention and treatment of these cancers. Below is the running video from this great opportunity.
Video courtesy of BOLD Worldwide
In September 2014, the DeGregorio Family Foundation’s video, “Turning Fact Into Fiction: Stomach and Esophageal Cancer Research,” was released to bring awareness to these deadly diseases. Many thanks to Mind File Multimedia, Inc. for their beautiful work.
Video courtesy of Mind File Multimedia, Inc.
The DeGregorio Family Foundation supports research. Your gift will be used exclusively to support gastric and esophageal research and education. As an approved 501(c)(3) organization under the Internal Revenue code, gifts made to the foundation are tax deductible to the fullest extent of the law. Make a Donation and Support the Foundation »
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