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DeGregorio Family Foundation Rooftop Gala 2016

Thank you for attending, donating and sponsoring our “Party on the Rooftop”  – Celebrating 10 years!

Without your generosity and support the DeGregorio Family Foundation could not continue supporting research into the causes, treatments and cures for stomach and esophageal cancers.

See ALL the photos from the evening on our Shutterfly page!

roof2016_03 roof2016_02 roof2016_01

tcsTEAM DEGREGORIO TO RUN in the TCS New York City Marathon
Less than one month to go!

Help us reach our goal!
Visit our Crowdrise page and see our team!

On Sunday, November 6, 2016, 10 runners from across the country will represent The DeGregorio Family Foundation in the TCS NYC Marathon.  Our team is hard at work raising money to help fund research grant opportunities for esophageal and stomach cancer.  We are thrilled to have these great runners on board with Team DeGregorio!  Wish them luck in November as they run New York City!


Deadline: November 1, 2016. Up to $250,000 over two years will be awarded. 

Funding Period: January 15, 2017- December 31, 2018

Amount: $250,000 for entire grant period. ($225,000 direct, $25,000 indirect).

Eligibility: Investigators must be associated with an academic or medical institution possessing a tax-exempt status under section 501 (c)(3) of the IRS code. Research projects must not be funded currently under a separate mechanism.

Research projects are selected through a rigorous review process, and project goals must align with The DeGregorio Family Foundation’s mission. The Foundation’s application review process is guided by its Scientific Advisory Board. Criteria for successful grants are impact, likelihood of completion and making a significant contribution to understanding, diagnosis, or treating gastric or esophageal malignancies. The intention of this award is to provided seed funding for research in upper GI malignancies. Funded applicants are expected to apply for subsequent peer reviewed support (i.e. NIH or similar agency).

Funding will be divided into three installments.  The first installment will be provided when appropriate institutional approvals are submitted and the study is underway.  The 2nd installment is contingent upon submission and review of an interim report at 1 year, and the final installment will be contingent on receipt of a final study report.

Any publications or presentations resulting from this research must be acknowledged.

Please use our online Application form or this Word version of the application form, and the research summary form. . For full foundation award details, click here

Please submit grant applications directly both to Lynn DeGregorio ( and Manish Shah, MD (



Dr. Manish Shah, The DeGregorio Family Foundation’s Scientific Advisory Board Chairman, recently teamed up with a biologist and gastroenterologist to conduct a study to better understand the workings of the gastrointestinal microbiota and metabolome.  Shah

For the full article on Dr. Shah’s latest scientific study and progress, please click here.





“Targeting Mk2 for Treatment of Gastric Cancer” — Dr. Ellen Beswick, University of New Mexico School of Medicine

 The DeGregorio Family Foundation is thrilled to announce that Dr.Ellen Beswick, PhD., Associate Professor of he UNM Department of Molecular Genetics and Biology has been awarded a $215,000 grant to further the study.

Gastric Cancer is the 4th most common cancer worldwide with a 5 year survival rate of only 20%.  Gastric cancer is highly associated with H. pylori infection, with infected individuals having a 3 to 6-fold higher risk of developing gastric cancer.  Despite these numbers, there are very few treatment options for gastric cancer beyond surgery.  Our data suggests that the MAP kinase-activated protein kinase 2 (MK2) signaling induced by H. pylori infection may be at the core of damaging inflammation and tumorigenesis.  We will examine inhibition of this pathway as a potential treatment approach to prevent and treat gastric cancer..


Dr. Ellen Beswick, Ph.D.

ellen in lab

Dr. Beswick in the UNM lab

Congratulations to Dr. Beswick and The University of New Mexico School of Medicine.  “We are excited to support Dr. Beswick’s research,” states Lynn DeGregorio, founder of The DeGregorio Family Foundation.

For more details from the article click here.

“Esophageal Cancer Screening Study” –Dr. William Grady, Fred Hutchinson Cancer Research Center

The DeGregorio Family Foundation, along with the Price Family Foundation, is pleased to announce the recipient of a $180,000 grant to Dr. William Grady, a clinical researcher and cancer geneticist at the Fred Hutchinson Cancer Research Center in Seattle, WA.

Studio portrait of Dr. William M. Grady, gastroenterology and internal medicine.

Dr. William M. Grady, gastroenterology and internal medicine.

At Fred Hutch, Dr. Grady will research more effective ways to identify people at a higher risk for esophageal adenocarcinoma, the most common cancer of the esophagus.  Last year alone, approximately 20,000 Americans died from cancer of the esophagus.  The DeGregorio Foundation, along with the contribution by the Price Family Foundation, is happy to support Dr. Grady’s research. “This year was our most competitive application process yet,” stated Lynn DeGregorio, founder and president.

For the full press release, please click here: Fred Hutch Researcher Receives Grant For Esophageal Screening Study

6th Annual DeGregorio Foundation Award for Cancers of the Esophagus and Stomach Application Closed

The DeGregorio Family Foundation for Gastric and Esophageal Cancer ( has closed its 6th annual funding opportunity for gastroesophageal malignancies.  The Foundation is excited about the potential research opportunities. Applications were sent in not only nationally, but internationally. DFF seeks to promote and facilitate collaborative research on the pathogenesis, early diagnosis, and treatment of upper gastrointestinal malignancies.  We support high quality, innovative, and transformative translational and bench research to improve the understanding of the biology of these diseases, identification of potential novel therapeutic targets, or in the development and evaluation of novel biomarkers for early diagnosis and treatment.  Pre-clinical research, basic mechanistic studies, genomic/epigenomic studies, as well as epidemiologic studies may also be supported.

Thank you to all of those who have applied. The winners will be announced in 2016.


DeGregorio Grant Leads to Million Dollar Award to Continue Research


Dr. Manish Shah

The DeGregorio Family Foundation would like to congratulate Manish Shah, MD and his team on their award of a $1,000,000 grant from The Starr Cancer Consortium (SCC)!

In 2011, DFF funded a $100,000 grant to Shah for the study of H. Pylori infection and Gastric Cancer Carcinogenesis. After presenting data collected from these studies, the SCC announced their additional grant for continued research of this important and innovative study. The following summary outlines the project and objectives.

The Impact of the Gastric Microbiome on Gastric Cancer Development

Principal Investigator:

  • Manish Shah, MD, Weill Cornell Medical College

Co-Principal Investigators:

  • Adam Bass, MD, The Broad Institute of MIT & Harvard
  • Doron Betel, PhD, Weill Cornell Medical College
  • Eric Pamer, MD, Memorial Sloan Kettering Cancer Center
  • Nikolas Schultz, PhD, Memorial Sloan Kettering Cancer Center

Although Helicobacter pylori infection is the most prevalent cause of gastric cancer worldwide, the molecular mechanisms leading to the development of malignancy as a consequence of infection remain unknown.  It is the realization that of a gastric microbiome that may also play an important role in chronic gastric inflammation and gastric cancer carcinogenesis.  Data regarding the relationship between H.pylori infection and the gastric microbiome and the concomitant changes in mucosal and adaptive immunity are lacking.  We plan to examine the gastric microbiome in patients with and without H.pylori infection as well as in patients with and without H.pylori associated gastric cancer.  We will couple this investigation with an examination of the mucosal immune infiltrate to provide data on the characteristics of both the microbiome associated with H.pylori infection as well as the consequences on host immunity.  We will also examine genetic differences between gastric cancer that developed in the setting of chronic H.pylori associated inflammation and non-H.pylori associated gastric cancer.  Together, these data will provide the necessary foundation for understanding the role the gastric microbiome plays in developing gastric cancer, and will form the basis for subsequent mechanistic and clinical studies for which NIH peer reviewed funding will be sought. Read more about the Starr Cancer Consortium Grant here.

The DeGregorio Family Foundation and the Price Family Foundation Congratulate Joint Recipients of Collaborative Research Grant

The DeGregorio Family Foundation and the Price Family Foundation congratulate Adam Bass MD and Timothy Wang MD, joint recipients of our collaborative research grant.

Our grant program brings critical funding to top academic researchers, enabling them to expand their scientific discoveries and build new collaborations. The Bass/Wang grant will support further study in gastric cancer – specifically Diffuse Gastric Cancer (DGC). It will allow Drs. Bass and Wang to l continue their research on the role of Novel RHO Pathway Genomic Alterations in DGC.

Read more about their innovative work here.

Bass Wang 1



EHE International 2014 Window Display Donation

EHE International’s generous donation of their window display at 10 Rockefeller Center increased awareness of Stomach and Esophageal Cancer and the need for funding research into the causes, prevention and treatment of these cancers. Below is the running video from this great opportunity.

Video courtesy of BOLD Worldwide




Foundation’s 2014 Video Release “Turning Fact Into Fiction: Stomach & Esophageal Cancer Research”

In September 2014, the DeGregorio Family Foundation’s video, “Turning Fact Into Fiction: Stomach and Esophageal Cancer Research,” was released to bring awareness to these deadly diseases. Many thanks to Mind File Multimedia, Inc. for their beautiful work.

Video courtesy of Mind File Multimedia, Inc.



 Make a Donation. Support the DeGregorio Family Foundation. 

The DeGregorio Family Foundation supports research. Your gift will be used exclusively to support gastric and esophageal research and education. As an approved 501(c)(3) organization under the Internal Revenue code, gifts made to the foundation are tax deductible to the fullest extent of the law. Make a Donation and Support the Foundation »

Click here to download the latest DeGregorio Family Foundation Brochure.




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