“Targeting Mk2 for Treatment of Gastric Cancer” — Dr. Ellen Beswick, University of New Mexico School of Medicine

 The DeGregorio Family Foundation is thrilled to announce that Dr.Ellen Beswick, PhD., Associate Professor of he UNM Department of Molecular Genetics and Biology has been awarded a $215,000 grant to further the study.

Gastric Cancer is the 4th most common cancer worldwide with a 5 year survival rate of only 20%.  Gastric cancer is highly associated with H. pylori infection, with infected individuals having a 3 to 6-fold higher risk of developing gastric cancer.  Despite these numbers, there are very few treatment options for gastric cancer beyond surgery.  Our data suggests that the MAP kinase-activated protein kinase 2 (MK2) signaling induced by H. pylori infection may be at the core of damaging inflammation and tumorigenesis.  We will examine inhibition of this pathway as a potential treatment approach to prevent and treat gastric cancer..


Dr. Ellen Beswick, Ph.D.

ellen in lab

Dr. Beswick in the UNM lab

Congratulations to Dr. Beswick and The University of New Mexico School of Medicine.  “We are excited to support Dr. Beswick’s research,” states Lynn DeGregorio, founder of The DeGregorio Family Foundation.

For more details from the article click here.

“Esophageal Cancer Screening Study” –Dr. William Grady, Fred Hutchinson Cancer Research Center

The DeGregorio Family Foundation, along with the Price Family Foundation, is pleased to announce the recipient of a $180,000 grant to Dr. William Grady, a clinical researcher and cancer geneticist at the Fred Hutchinson Cancer Research Center in Seattle, WA.

Studio portrait of Dr. William M. Grady, gastroenterology and internal medicine.

Dr. William M. Grady, gastroenterology and internal medicine.

At Fred Hutch, Dr. Grady will research more effective ways to identify people at a higher risk for esophageal adenocarcinoma, the most common cancer of the esophagus.  Last year alone, approximately 20,000 Americans died from cancer of the esophagus.  The DeGregorio Foundation, along with the contribution by the Price Family Foundation, is happy to support Dr. Grady’s research. “This year was our most competitive application process yet,” stated Lynn DeGregorio, founder and president.

For the full press release, please click here: Fred Hutch Researcher Receives Grant For Esophageal Screening Study

6th Annual DeGregorio Foundation Award for Cancers of the Esophagus and Stomach Application Closed

The DeGregorio Family Foundation for Gastric and Esophageal Cancer (www.DeGregorio.org) has closed its 6th annual funding opportunity for gastroesophageal malignancies.  The Foundation is excited about the potential research opportunities. Applications were sent in not only nationally, but internationally. DFF seeks to promote and facilitate collaborative research on the pathogenesis, early diagnosis, and treatment of upper gastrointestinal malignancies.  We support high quality, innovative, and transformative translational and bench research to improve the understanding of the biology of these diseases, identification of potential novel therapeutic targets, or in the development and evaluation of novel biomarkers for early diagnosis and treatment.  Pre-clinical research, basic mechanistic studies, genomic/epigenomic studies, as well as epidemiologic studies may also be supported.

Thank you to all of those who have applied. The winners will be announced in 2016.

Team DeGregorio is Running the United Airlines NYC Half Marathon 2016!


The DeGregorio Family Foundation’s team of runners is training and turning fact into fiction by raising money for the NYC Half Marathon on March 20th, 2016.

All money raised will go to the research and education of stomach and esophageal cancer.

To learn how you can get involved with future races with Team DeGregorio, click here

For more information about the race itself, click here





DeGregorio Grant Leads to Million Dollar Award to Continue Research


Dr. Manish Shah

The DeGregorio Family Foundation would like to congratulate Manish Shah, MD and his team on their award of a $1,000,000 grant from The Starr Cancer Consortium (SCC)!

In 2011, DFF funded a $100,000 grant to Shah for the study of H. Pylori infection and Gastric Cancer Carcinogenesis. After presenting data collected from these studies, the SCC announced their additional grant for continued research of this important and innovative study. The following summary outlines the project and objectives.

The Impact of the Gastric Microbiome on Gastric Cancer Development

Principal Investigator:

  • Manish Shah, MD, Weill Cornell Medical College

Co-Principal Investigators:

  • Adam Bass, MD, The Broad Institute of MIT & Harvard
  • Doron Betel, PhD, Weill Cornell Medical College
  • Eric Pamer, MD, Memorial Sloan Kettering Cancer Center
  • Nikolas Schultz, PhD, Memorial Sloan Kettering Cancer Center

Although Helicobacter pylori infection is the most prevalent cause of gastric cancer worldwide, the molecular mechanisms leading to the development of malignancy as a consequence of infection remain unknown.  It is the realization that of a gastric microbiome that may also play an important role in chronic gastric inflammation and gastric cancer carcinogenesis.  Data regarding the relationship between H.pylori infection and the gastric microbiome and the concomitant changes in mucosal and adaptive immunity are lacking.  We plan to examine the gastric microbiome in patients with and without H.pylori infection as well as in patients with and without H.pylori associated gastric cancer.  We will couple this investigation with an examination of the mucosal immune infiltrate to provide data on the characteristics of both the microbiome associated with H.pylori infection as well as the consequences on host immunity.  We will also examine genetic differences between gastric cancer that developed in the setting of chronic H.pylori associated inflammation and non-H.pylori associated gastric cancer.  Together, these data will provide the necessary foundation for understanding the role the gastric microbiome plays in developing gastric cancer, and will form the basis for subsequent mechanistic and clinical studies for which NIH peer reviewed funding will be sought. Read more about the Starr Cancer Consortium Grant here.

The DeGregorio Family Foundation and the Price Family Foundation Congratulate Joint Recipients of Collaborative Research Grant

The DeGregorio Family Foundation and the Price Family Foundation congratulate Adam Bass MD and Timothy Wang MD, joint recipients of our collaborative research grant.

Our grant program brings critical funding to top academic researchers, enabling them to expand their scientific discoveries and build new collaborations. The Bass/Wang grant will support further study in gastric cancer – specifically Diffuse Gastric Cancer (DGC). It will allow Drs. Bass and Wang to l continue their research on the role of Novel RHO Pathway Genomic Alterations in DGC.

Read more about their innovative work here.

Bass Wang 1


2015 DeGregorio Grant Winner Announced

Phillip Smith

Phillip Smith, MD

The DeGregorio Family Foundation would like to congratulate Phillip Smith, MD as one of the two recipients of our grant program. He currently teaches at the University of Alabama at Birmingham. These grants bring critical funding to many of the top academic researchers wanting to expand their scientific discoveries and build new collaborations for further research on gastric cancer; specifically H. pylori infection.

H. pylori infection of the stomach is the major cause of gastric cancer worldwide. This infection typically begins earlier in life during childhood and persists into adulthood. Children do not develop H.pylori-induced gastric cancer, whereas adults do. In fact, gastric cancer is exclusively present in adults. This application and research study seeks to determine how children suppress or down-regulate the H. pylori-induced gastric inflammatory changes that lead to cancer of the stomach. It is hypothesized in this research study that although everyone’s stomach is colonized by millions of bacteria (the gastric microbiota), the gastric microbiota of H. pylori-infected children, but not adults, promotes suppression of H. pylori-induced gastric inflammation and its attendant precancerous lesions. Thus, this suppression prevents H. pylori induced gastric cancer in children.

We look forward to hearing further on this research, and again congratulate Phillip Smith, MD for his achievement and study of gastric cancer.

EHE International 2014 Window Display Donation

EHE International’s generous donation of their window display at 10 Rockefeller Center increased awareness of Stomach and Esophageal Cancer and the need for funding research into the causes, prevention and treatment of these cancers. Below is the running video from this great opportunity.

Video courtesy of BOLD Worldwide




Foundation’s 2014 Video Release “Turning Fact Into Fiction: Stomach & Esophageal Cancer Research”

In September 2014, the DeGregorio Family Foundation’s video, “Turning Fact Into Fiction: Stomach and Esophageal Cancer Research,” was released to bring awareness to these deadly diseases. Many thanks to Mind File Multimedia, Inc. for their beautiful work.

Video courtesy of Mind File Multimedia, Inc.



 Make a Donation. Support the DeGregorio Family Foundation. 

The DeGregorio Family Foundation supports research. Your gift will be used exclusively to support gastric and esophageal research and education. As an approved 501(c)(3) organization under the Internal Revenue code, gifts made to the foundation are tax deductible to the fullest extent of the law. Make a Donation and Support the Foundation »

Click here to download the latest DeGregorio Family Foundation Brochure.




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