On a very personal note we are soon going to publish an article of my
relative’s story on our website, however, I wanted to share this story.
I recently discovered I have a relative, Jerry, who was adopted. For his
45th birthday his wife gave him Ancestry.com’s DNA testing to find family.
Thanks to this test he was able to find his birth mother on Ancestry.com.
When he contacted her she was then able to give him the name of his birth
father for him to research. After google searches and cold-calling he found
Jerry’s father is CDH1 positive and Jerry is around the age where most
of our family members were diagnosed with HDGC. When he told Jerry
this he suggested Jerry contact me. I sent Jerry to the NIH, he enrolled
in their study, and he discovered he was positive for the family mutation.
As many familiar with the CDH1 mutation know an endoscopy can be
unreliable method to find cancer at an early stage therefore prophylactic
gastrectomy is usually recommended. Last month Jerry had his stomach
removed. He had Stage 1 stomach cancer.
We are extremely lucky to have been a part of Jerry’s recovery. Had his wife
decided to wait to gift him a DNA test by a few years this story may have had
a very different ending. We continue our ongoing effort to beat this cancer in
determination to have more stories like Jerry’s.
In Memory of Mike Todd.
The DeGregorio Family and the Savone Family have awarded Adam Snook, PhD(left), of the Department of Pharmacology and Experimental Therapeutics at the Sidney Kimmel Cancer Center and Sidney Kimmel Medical College at Jefferson $175,000 grant to study the effectiveness of CAR-T therapy as a treatment for gastroesophageal cancers. Read the full press release here.
The Price Family Foundation and the DeGregorio Family Foundation have awarded Dechen Lin, PhD(right), a research scientist in the Division of Hematology and Oncology in the Cedars-Sinai Department of Medicine$175,000.Read the full press release here.
9th Annual DeGregorio Foundation Award for Cancers of the Esophagus and Stomach
Deadline: November 7, 2018. Up to $250,000 over two years will be awarded.
Funding Period: January 15, 2018- December 31, 2020
Amount: $250,000 for entire grant period. ($225,000 direct, $25,000 indirect).
Choose one of these ways to submit your grant application.
The Foundation seeks to promote and facilitate collaborative research on the pathogenesis, early diagnosis, and treatment of upper gastrointestinal malignancies. We support high quality, innovative, and transformative translational and bench research to improve the understanding of the biology of these diseases, identification of potential novel therapeutic targets, or in the development and evaluation of novel biomarkers for early diagnosis and treatment. Pre-clinical research, basic mechanistic studies, genomic/epigenomic studies, as well as epidemiologic studies may also be supported.
Esophageal adenocarcinoma (EAC) is the fastest growing lethal malignancy in the West. Gastro-esophageal reflux disease (GERD) is a chronic-inflammatory disorder associated with an 8 fold increased risk of EAC. Interactions between the epithelium and the underlying stromal layer may be critical to elucidating the link between gastrointestinal inflammatory disorders such as GERD and esophageal cancer. The spindle-shaped myofibroblast, one of the cell types in the esophageal stroma, is a focus of our laboratory. Our work suggests that esophageal myofibroblasts regulate mucosal inflammation, injury, and repair processes in the human esophagus via secretion of a number of signaling mediators, including cytokines and growth factors. With the DeGregorio Foundation grant, we will investigate these interactions by adapting myofibroblasts from GERD patients into 3D organotypic (OTC) models that recapitulate human esophageal stratified squamous epithelium. We hope to delineate the inter-cellular cross talk in GERD that when disrupted leads to esophageal carcinogenesis
He will begin clinical trials of a potential approach for reversing precancerous stomach lesions. Check back, we have exciting details to come!
Tony E. Godfrey, PhD, Associate Chair, Surgical Research and Associate Professor of Surgery, Boston University School of Medicine, earned a bachelor’s of science degree in biochemistry from Brunel University in England, followed by a doctorate in molecular biology and biochemistry, also from Brunel. He attended the University of California, San Francisco, for postdoctoral fellowships and managed UCSF’s Genome Analysis Core Facility.
Most recently, Dr. Godfrey was a Research Associate Professor in the Department of Surgery at the University of Rochester Medical Center in Rochester, NY. Prior to this he was an Associate Professor of Pathology at Mt. Sinai School of Medicine in New York, NY.
Dr. Godfrey’s research is focused on cancer genetics and molecular pathology. Research projects use state-of-the-art genetic and genomic approaches to address clinical needs in the areas of cancer diagnosis, prognosis and therapy. Currently the major focus of Dr. Godfrey’s research is on Barrett’s esophagus and esophageal adenocarcinoma; a tumor with rapidly increasing incidence in the United States and other western countries. The Godfrey lab works closely with translational research teams comprised of surgeons, pathologists and oncologists in order to develop new molecular approaches to cancer detection, staging and treatment.
Click Here to read more about Dr. Godfrey’s research and a complete list of his published reports
EHE International’s generous donation of their window display at 10 Rockefeller Center increased awareness of Stomach and Esophageal Cancer and the need for funding research into the causes, prevention and treatment of these cancers. Below is the running video from this great opportunity.
Video courtesy of BOLD Worldwide
In September 2014, the DeGregorio Family Foundation’s video, “Turning Fact Into Fiction: Stomach and Esophageal Cancer Research,” was released to bring awareness to these deadly diseases. Many thanks to Mind File Multimedia, Inc. for their beautiful work.
Video courtesy of Mind File Multimedia, Inc.
The DeGregorio Family Foundation supports research. Your gift will be used exclusively to support gastric and esophageal research and education. As an approved 501(c)(3) organization under the Internal Revenue code, gifts made to the foundation are tax deductible to the fullest extent of the law. Make a Donation and Support the Foundation »
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