The DeGregorio Family Foundation and the Price Family Foundation congratulate Adam Bass MD and Timothy Wang MD, joint recipients of our collaborative research grant.
Our grant program brings critical funding to top academic researchers, enabling them to expand their scientific discoveries and build new collaborations. The Bass/Wang grant will support further study in gastric cancer – specifically Diffuse Gastric Cancer (DGC). It will allow Drs. Bass and Wang to l continue their research on the role of Novel RHO Pathway Genomic Alterations in DGC.
Read more about their innovative work here.
The Degregorio Family Foundation would like to congratulate Phillip Smith, MD as one of the two recipients of our grant program. He currently teaches at the University of Alabama at Birmingham. These grants bring critical funding to many of the top academic researchers wanting to expand their scientific discoveries and build new collaborations for further research on gastric cancer; specifically H. pylori infection.
H. pylori infection of the stomach is the major cause of gastric cancer worldwide. This infection typically begins earlier in life during childhood and persists into adulthood. Children do not develop H.pylori-induced gastric cancer, whereas adults do. In fact, gastric cancer is exclusively present in adults. This application and research study seeks to determine how children suppress or down-regulate the H. pylori-induced gastric inflammatory changes that lead to cancer of the stomach. It is hypothesized in this research study that although everyone’s stomach is colonized by millions of bacteria (the gastric microbiota), the gastric microbiota of H. pylori-infected children, but not adults, promotes suppression of H. pylori-induced gastric inflammation and its attendant precancerous lesions. Thus, this suppression prevents H. pylori induced gastric cancer in children.
We look forward to hearing further on this research, and again congratulate Phillip Smith, MD for his achievement and study of gastric cancer.
The DeGregorio Family Foundation would like to congratulate Manish Shah, MD and his team on their award of a $1,000,000 grant from The Starr Cancer Consortium (SCC)!
In 2011, DFF funded a $100,000 grant to Shah for the study of H. Pylori infection and Gastric Cancer Carcinogenesis. After presenting data collected from these studies, the SCC announced their additional grant for continued research of this important and innovative study. The following summary outlines the project and objectives.
The Impact of the Gastric Microbiome on Gastric Cancer Development
Although Helicobacter pylori infection is the most prevalent cause of gastric cancer worldwide, the molecular mechanisms leading to the development of malignancy as a consequence of infection remain unknown. It is the realization that of a gastric microbiome that may also play an important role in chronic gastric inflammation and gastric cancer carcinogenesis. Data regarding the relationship between H.pylori infection and the gastric microbiome and the concomitant changes in mucosal and adaptive immunity are lacking. We plan to examine the gastric microbiome in patients with and without H.pylori infection as well as in patients with and without H.pylori associated gastric cancer. We will couple this investigation with an examination of the mucosal immune infiltrate to provide data on the characteristics of both the microbiome associated with H.pylori infection as well as the consequences on host immunity. We will also examine genetic differences between gastric cancer that developed in the setting of chronic H.pylori associated inflammation and non-H.pylori associated gastric cancer. Together, these data will provide the necessary foundation for understanding the role the gastric microbiome plays in developing gastric cancer, and will form the basis for subsequent mechanistic and clinical studies for which NIH peer reviewed funding will be sought. Read more about the Starr Cancer Consortium Grant here.
EHE International’s generous donation of their window display at 10 Rockefeller Center increased awareness of Stomach and Esophageal Cancer and the need for funding research into the causes, prevention and treatment of these cancers. Below is the running video from this great opportunity.
Video courtesy of BOLD Worldwide
In September 2014, the DeGregorio Family Foundation’s video, “Turning Fact Into Fiction: Stomach and Esophageal Cancer Research,” was released to bring awareness to these deadly diseases. Many thanks to Mind File Multimedia, Inc. for their beautiful work.
Video courtesy of Mind File Multimedia, Inc.
The DeGregorio Family Foundation is participating in the United Airlines Half-Marathon on Sunday, March 15, 2015. We would like to welcome our runners:
Mark March 15th on your calendars and come out and support Team DFF! If you would like to donate and support our runners you can find them on Crowdrise. All money raised will go to the research and education of stomach and esophageal cancer.
All money raised will go to the research and education of stomach and esophageal cancer.
November 2014 was DFF’s Third Annual The Great Network Next Mustache-Off! We had a great group of men & women supporting stomach and esophageal cancer research right in their office. Thank you Adam and Shell Oil for another successful year!
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